针刺对实验性骨质疏松大鼠股骨骨折的预防作用

目的研究"健脾益肾强骨针法"对去势SD大鼠股骨骨质疏松性骨折的预防作用。方法 6月龄SD大鼠在去势3个月检测骨质疏松症模型造模成功后,被随机分为3个组:对照组、阿仑膦酸钠组和针刺组。针刺组针刺足三里、肾俞、大杼,每日1次,每周5次,连续治疗6个月;阿仑膦酸钠组每日皮下注射阿仑膦酸钠,每日1次,连续治疗6个月;对照组每日在其他两组治疗期间进行同样抓放。治疗6个月后,检测包括在体股骨骨折最小外力、新鲜股骨形态学、骨密度、骨力学性能等反映股骨的硬度和弹性的指标。结果针刺组、阿仑膦酸钠组的在体股骨骨折最小外力明显大于对照组;针刺组新鲜股骨近端横径明显小于阿仑膦酸钠组和对照组;针刺组、阿仑膦酸钠组骨密度明显大于对照组;针刺组、阿仑膦酸钠组离体股骨的部分力学性能指标(如压缩、拉伸)明显高于对照组。结论 1针刺足三里、肾俞、大杼6个月具有预防绝经后骨质疏松症模型大鼠股骨骨折的作用,其机制可能与针刺促进股骨的形态适应、增加骨密度、提高骨的抗外力性能密切相关。2"健脾益肾强骨针法"与阿仑膦酸钠均能提高绝经后骨质疏松大鼠在体股骨骨折最小外力,但针刺的作用机制与阿仑膦酸钠不完全相同。

The effective of acupuncture on the prevention of osteoporotic femoral fraction in experimental osteoporosis rats

Objective To study to the effect of strengthen the spleen, benefiting the kidney, and strengthen the bone acupuncture method on the prevention of the femoral fracture in ovariectomized SD rats. Methods The 6-month-old SD rats were divided into 3 groups after 3-mongth ovariectomy, control group (C), alendronate group (AS), and acupuncture group (A). Rats in acupuncture group received acupuncture at Zusanli (ST36), Shenshu (BL23), and Dazhu (BL11) points once a day, 5 times a week, for 6 months. Rats in alendronate group were injected subcutaneously with alendronate sodium. Rats in control group were released and captured like the other two groups. The minimum external force, histomorphometry, bone mineral density (BMD), and bone mechanics were examined after 6-month treatment. Results The minimum external force of femur fractures in vivo in group A and group AS was significantly greater than that in group C. The fresh femoral proximal transverse diameter in group A was obviously smaller than that in group C and group AS. BMC in group A and AS group was significantly higher than that in group C. Conclusion 1. Acupuncture at ST36, BL23, and BL11 for 6 months is effective in prevention of hip fracture in postmenopausal osteoporosis model rats. Its mechanism may be closely related to promoting femoral morphological adaptation, increasing femur BMD, and increasing the ability of resistance of external force. 2. The acting mechanism of acupuncture and alendronate sodium is not identical.