| RAS抑制剂的骨生物学作用研究进展 |
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| 引用本文： | 沙南南,李晓莉王拥军,张岩.RAS抑制剂的骨生物学作用研究进展[J].中国骨质疏松杂志,2017(8):1117-1120. |
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| 作者姓名： | 沙南南 李晓莉王拥军 张岩 |
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| 作者单位： | 1.上海中医药大学跗属龙华医院，上海200032
2.上海中医药大学脊柱病研究所，上海200032
3.上海理工大学医疔器械与食品学院.，上海200093
4.上海中医药大学康复医学院，上海201203 |
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| 基金项目： | 国家中医临床研究基地项目-龙医创新团队（LYCX-01）;上海市自然科学基金（17ZR1430800) |
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| 摘 要： | 近来研究显示,骨组织、骨细胞存在肾素-血管紧张素系统(RAS)组分。功能性研究发现骨骼RAS参与了骨质疏松症的发生、发展,充分揭示了骨骼RAS在骨代谢中的重要作用。本文综述了血管紧张素转化酶抑制剂、血管紧张素受体拮抗剂对骨代谢的改善作用与不利影响。本文有助于更好地理解组织RAS在调控骨健康中的生物学作用,为临床应用RAS抑制剂治疗高血压或糖尿病并发症患者的用药具有指导意义。
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| 关 键 词： | 肾素-血管紧张素系统 血管紧张素II 血管紧张素转化酶抑制剂 血管紧张素受体拮抗剂 骨质疏松 |
Research progress on the bone biological effects of RAS inhibitors |
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| SHA Nannan,LI Xiaoli,WANG Yongjun,ZHANG Yan.Research progress on the bone biological effects of RAS inhibitors[J].Chinese Journal of Osteoporosis,2017(8):1117-1120. |
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| Authors: | SHA Nannan LI Xiaoli WANG Yongjun ZHANG Yan |
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| Institution: | 1.Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032
2.Spine Disease Research Institute, Shanghai University of Traditional Chinese Medicine, Shanghai 200032
3.School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093
4.School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203 |
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| Abstract: | Recent studies have revealed the existence of renin-angiotensin system (RAS) components in bone tissue and bone cells. Functional studies demonstrated the involvement of skeletal RAS in the occurrence and development of osteoporosis, suggesting the important roles of skeletal RAS on bone metabolism. In this review we summarized the beneficial and detrimental effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on bone metabolism. The information from this review will be valuable for the better understanding of the biological effects of local RAS on bone health, as well as provide clinical guidance when the RAS inhibitors are prescribed for patients with hypertension or diabetic complications. |
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