绝经后非老年女性血清GDF11浓度及其与骨质疏松发病的关系

目的观察绝经后非老年女性人群循环中GDF11浓度的变化,探讨其与骨质疏松症发病的关系及其是否可作为该年龄组人群骨质疏松症发病的预测指标。方法收集绝经后非老年女性人群空腹血清,使用GDF11特异性ELISA方法检测受试者血清GDF11浓度。对所有受试者后前位腰椎1-4及左侧髋部进行双能X线骨密度测定。使用SPSS软件进行GDF11浓度与BMD值相关性的分析。按血清GDF11四分位数将受试者进行分组,比较各组骨质疏松症发病率并计算组间骨质疏松症发病风险比值比。结果在此人群中,GDF11与骨密度呈负性相关。高GDF11人群组骨质疏松症发病率显著高于低GDF11人群组。高GDF11人群组骨质疏松症发病风险明显高于低GDF11人群组。结论在绝经后非老年女性人群中,血清GDF11浓度与BMD值呈负性相关;GDF11浓度升高与骨质疏松症发病相关且可作为骨质疏松症发病的预测指标。

The relationship between serum GDF11 levels and the prevalence of osteoporosis in non-elderly postmenopausal women

Objective To observe the changes in serum growth differentiation factor 11.(GDF11) levels in non-elderly postmenopausal women, evaluate its relationship with the prevalence of osteoporosis and its predictive value for osteoporosis in the study participants. Methods The concentrations of fasting serum GDF11 were determined by a GDF11-specific immunoassay. Bone mineral density (BMD) of lumbar spine (L1-L4) and left hip was measured by dual-energy X-ray absorptiometry. Correlations between GDF11 and BMD and the relationship between GDF11 and the risk for osteoporosis were calculated using SPSS. Results Our data showed negative correlations between serum GDF11 levels and BMD at the lumbar spine and femoral neck. The serum GDF11 levels were grouped according to quartile intervals, and the prevalence and risk of osteoporosis were found be significantly greater with increased GDF11 levels. Conclusion This study demonstrated that GDF11 was negatively correlated with BMD in non-elderly postmenopausal women. Furthermore, osteoporotic risk increased significantly with increases in GDF11 levels. GDF11 was a predictor of osteoporosis in our study participants.