新疆乌鲁木齐市某社区维吾尔族女性跟骨骨密度与代谢综合征相关性分析

目的探索代谢综合征(MS)与不同年龄及代谢状态下维吾尔族女性定量骨超声检测跟骨骨密度(T值)与其之间的相关性。方法横断面研究,对象为新疆乌鲁木齐市二道桥某社区常住维族女性。按年龄分组,观察不同年龄段维族女性骨量的变化。按中华医学会糖尿病分会(CDS)1]诊断MS的诊断标准,将549名女性分为高血压组136例,血压正常组413例;糖尿病组103例,血糖正常组446例;单纯肥胖或超重组290例,体重正常组259例;血脂紊乱组157例,血脂正常组392例;MS组86例,非MS组463例。根据既往史是否绝经分为未绝经组339例,绝经组182例;并用线性回归分析,研究跟骨骨密度的独立影响因素。结果高血压、糖代谢异常、MS组骨量T值均低于其代谢正常组,差异有统计学意义(均P0.05);高血压、糖代谢异常、超重或肥胖、MS组骨量减少、骨质疏松的患病率均高于其代谢正常组,差异有统计学意义(均P0.05);按年龄分组,不同组间T值不完全相同,随年龄增长,骨量减少的患病率升高,差异有统计学意义(P0.05);按是否合并绝经分组,绝经组骨量减少、骨质疏松的患病率明显升高,差异有统计学意义(P0.05)。结论 MS作为多种代谢异常的症候群,骨量减少的患病率高,是骨质疏松发生的高风险人群。绝经是女性骨量减少的独立危险因素。

Correlation analysis between calcaneal bone mineral density and metabolic syndrome in Uyghur women in a community of Urumqi, Xinjiang Uygur Autonomous Region

Objective To explore the correlation between metabolic syndrome (MS) and bone mineral density (T) of the calcaneus bone in Uygur women of different age and metabolic status. Methods A cross-sectional study was conducted in women in a community of Erdaoqiao, Urumqi, Xinjiang Uygur Autonomous Region. According to age, the women were grouped to observe the change of bone mass in different age groups. According to the diagnostic criteria of Diabetes Society (CDS) in the diagnosis of MS by Chinese Medical Association, 549 females were divided into hypertension group (n=136) and normal blood pressure group(n=413); diabetic group (n=103) and normal blood glucose group (n=446); obese or overweight group (n=290) and normal weight group (n=259); dyslipidemia group (n=157) and normal blood lipid group (n=392); and MS group (n=86) and non-MS group (n=463). According to the past history the women were divided into non-menopausal group (n=339) and postmenopausal group (n=182). The factors affecting the bone mass were studied with linear regression analysis. Results The T value was lower in hypertension, sugar metabolism, and MS group than that in MS normal group, and the difference was statistically significant (P<0.05). Osteoporosis prevalence was higher in hypertension, glucose metabolism abnormality, overweight or obesity, and MS group than that in MS normal group, and the difference was statistically significant (P<0.05). T value was different among age groups. With the age increase, the prevalence of bone loss increased, and the difference was statistically significant (P<0.05). The prevalence of osteoporosis significantly increased in postmenopausal group, and the difference was statistically significant (P<0.05). Conclusion The prevalence of bone mass loss is high in MS population. People with MS is a high risk group of osteoporosis. Menopause is an independent risk factor of bone loss in women.