血尿酸与骨密度相关性的研究进展

尿酸是嘌呤代谢的最终产物,是人体内一种重要的内源性抗氧化剂,在氧化应激方面发挥重要作用,而氧化应激是骨质疏松形成的一个独立的危险因素,因此,血尿酸与骨量丢失可能存在某种相关性。近年来,国内外对血尿酸与骨密度相关性的研究较多,但其确切关系仍存在争议。本文主要从不同人群血尿酸与骨密度相关性、二者相关性的可能机制、及其存在的争议等问题进行阐述,以期能进一步加深对二者的认识,为临床治疗研究提供新的思路。

Research progress on the relationship between serum uric acid and bone mineral density

Uric acid is the end product of purine metabolism. It is also an important endogenous antioxidant in the body and plays an important role in oxidative stress, which is an independent risk factor for osteoporosis. Therefore, there may be some correlations between serum uric acid and bone loss. In recent years, there are many researches on the correlations between serum uric acid and bone mineral density in both China and overseas, but the exact relationship is still controversial. This paper mainly elaborates the relationship between serum uric acid and bone mineral density in different populations, the possible mechanisms, and the controversy on their correlation, etc., in order to deepen the understanding of the two and to provide new ideas for research on clinical management.