鲑鱼降钙素结合脉冲电磁场治疗脊髓损伤致骨质疏松症的临床效果

目的观察鲑鱼降钙素联合低频脉冲电磁场治疗脊髓损伤所致骨质疏松症的临床效果。方法 2012年9月至2015年9月本科收治的脊髓损伤致骨质疏松症患者90例,按随机数字表法将其分为降钙素组(n=30)、电磁场组(n=30)及联合治疗组(n=30)。降钙素组给予鲑鱼降钙素治疗,电磁场组给予低频脉冲电磁场进行治疗,联合治疗组给予低频脉冲电磁场联合鲑鱼降钙素治疗,共3个月。测定治疗不同时间段患者疼痛视觉模拟评分(VAS),腰椎及股骨颈骨密度(BMD)及甲状旁腺素(PTH)、骨钙素(BGP)、1,25-双羟维生素D31,25-(OH)2D3]等生化指标的变化情况。结果治疗1、2、3个月及6个月后联合治疗组患者VAS评分显著低于降钙素组及电磁场组。治疗后,联合治疗组腰椎及股骨颈骨密度均显著高于降钙素组及电磁场组(P0.05);联合治疗组PTH、BGP均显著低于降钙素组及电磁场组(P0.05),1,25-(OH)2D3显著高于降钙素组及电磁场组(P0.05)。结论低频脉冲电磁场联合鲑鱼降钙素可有效减轻脊髓损伤所致骨质疏松症患者的骨性疼痛程度,提升患者骨密度。

Effect of salmon calcitonin combined with low frequency pulsed electromagnetic field on osteoporosis induced by spinal cord injury

Objective To explore the effect of salmon calcitonin combined with low frequency pulsed electromagnetic field on osteoporosis induced by spinal cord injury. Methods 90 patients with osteoporosis induced by spinal cord injury from September 2012 to September 2015 in our department were included. They were randomly divided into calcitonin group (n = 30), electromagnetic field group (n = 30), and combination therapy group (n = 30). Patients in the calcitonin group and electromagnetic field group received salmon calcitonin and low frequency-pulsed electromagnetic field treatment, respectively, while patients in the combination therapy group received salmon calcitonin combined with low frequency-pulsed electromagnetic field treatment, for 3 months. Visual analogue scale (VAS) of pain was evaluated in different periods. Bone mineral density (BMD) of the lumbar spine and femoral neck, parathyroid hormone (PTH), bone Gla protein (BGP), and 1,25-dihydroxy vitamin D3 (1,25-(OH)2 D3 ) were tested and recorded. Results The VAS score was lower in the combination therapy group than that in the calcitonin group and electromagnetic field group at 1, 2, 3, and 6 months after the treatment (P<0.05). BMD of the lumbar spine and femoral neck was significantly higher, PTH and BGP were significantly lower, and 1,25-(OH)2 D3 was significantly higher in the combination therapy group than those in the calcitonin group and electromagnetic field group after the treatment (P<0.05). Conclusion Combination of salmon calcitonin and low frequency-pulsed electromagnetic field can effectively reduce the bone pain and improve BMD in patients with osteoporosis induced by spinal cord injury.