丹参川芎制剂对治疗甲状腺癌术后甲状旁腺功能减退的临床研究

目的 探讨丹参川芎制剂对甲状腺癌术后低钙血症和甲状旁腺功能减退的疗效。 方法  选择2016年1月至2017年12月江苏省肿瘤医院头颈外科收治的30例甲状腺癌术后并发低钙血症和甲状旁腺功能减退患者。遵患者意愿，接受丹参川芎注射液治疗为观察组，共15例，在传统葡萄糖酸钙注射液和骨化三醇治疗基础上加用丹参川芎注射液；对照组予传统葡萄糖酸钙注射液和骨化三醇治疗，共15例。分析丹参川芎制剂对术后甲状旁腺功能减退的治疗效果。 结果  观察组和对照组术后第1天血钙水平相比，差异无统计学意义（P＞005）；观察组术后第3、7、30天血钙水平高于对照组，差异有统计学意义（P＜005）。观察组和对照组术后第1、3天血甲状旁腺激素（PTH）水平相比，差异无统计学意义（P＞005）；观察组术后第7、30天血钙水平高于对照组，差异有统计学意义（P＜005）。 结论  丹参川芎制剂对术后甲状旁腺功能减退及低钙血症治疗效果明显，且不良反应低，值得临床应用。

Clinical study of Salvia miltiorrhiza rhizome preparation in the treatment of hypoparathyroidism after thyroidectomy

Objective This study aimed to investigate the influencing factors for post-thyroidectomy hypocalcaemia and hypoparathyroidism as well as the prevention and treatment for postoperative hypocalcaemia by Salvia miltiorrhiza rhizome preparation. Methods A total of 30 patients undergoing thyroidectomy in Jiangsu Cancer Hospital were preoperatively and postoperatively assessed for hypocalcemia and hypoparathyroidism. Analyses were performed to evaluate for PTH and Serum calcium by Salvia miltiorrhiza rhizome preparation. Results Salvia miltiorrhiza Chuanxiong preparation improved the symptoms of hypoparathyroidism and hypoparathyroidism after operation. The elevated level in observation group was significantly lower than that in control group（P＜0.05）. The incidence of adverse reactions in the observation group was significantly lower than that in the control group（P＜0.05）. Conclusions The effect of Salvia miltiorrhiza rhizome preparation on postoperative hypoparathyroidism and hypocalcemia is obvious.