Intratumoral Lymphatic Vessels and VEGF-C Expression Are Predictive Factors of Lymph Node Relapse in T1-T4 N0 Laryngopharyngeal Squamous Cell Carcinoma |
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Authors: | Adolfo Hinojar-Gutiérrez María-Encarnación Fernández-Contreras Rocío González-González María-Jesús Fernández-Luque Adolfo Hinojar-Arzadún Miguel Quintanilla Carlos Gamallo |
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Affiliation: | (1) Department of Otorhynolaryngology, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain;(2) Department of Pathology, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain;(3) Department of Methodological Support Unit of the Foundation for Biomedical Research, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain;(4) Department of Cell Signaling, Instituto de Investigaciones Biomédicas “Alberto Sols”, Universidad Autónoma de Madrid (UAM), Madrid, Spain;(5) Servicio de Anatomía Patológica, Hospital Universitario de la Princesa, 2a Planta, C/ Diego de León, 62, 28006 Madrid, Spain |
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Abstract: | Background The presence of intratumoral lymphatic vessels (ILVs) and the expression of vascular endothelial growth factor-C (VEGF-C) in tumour cells have been studied as markers of lymphangiogenesis in order to evaluate their role in metastatic dissemination in laryngopharyngeal squamous cell carcinoma. Methods A retrospective study was performed in 76 patients of N0 laryngopharyngeal carcinoma. with variable tumour size (T1-T4), histological grade, and location (supraglottic, glottic and hypopharyngeal). The presence of ILVs, as revealed by the expression of PA2.26 antigen and VEGF-C expression, were determined by immunohistochemistry (IHC). Low-grade and high-grade lymphangiogenesis were defined by qualitative and quantitative criteria. Results Multivariate analysis revealed low-grade ILV and VEGF-C expression to be associated respectively with 30.3- and 16.2-fold higher probabilities of cervical lymph node relapse (P = 0.005 and P = 0.032) and with 16.2- and 8.44-fold shorter disease-free survival (P = 0.009 and P = 0.045). Conclusions Low-grade ILV and VEGF-C expression are independent predictive factors of cervical lymph node relapse and shortening of time to relapse in N0 laryngopharyngeal carcinoma. |
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Keywords: | VEGF-C Lymphangiogenesis Intratumoral lymphatic vessels Larynx |
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