支气管哮喘患者血清IL-33水平的变化及临床意义分析

目的 分析支气管哮喘患者血清IL-33水平的变化及临床意义。方法 选择本院收治的64例支气管哮喘患者为观察组,另选择同期于本院行健康体检的60例健康者为对照组,分别对两组对象的血清IL-33水平进行检测,并检测观察组患者的血清IgE及肺功能指标水平。对比和分析两组血清IL-33表达水平及观察组不同病情特点及严重程度的IgE及肺功能指标水平。结果 观察组的血清L-33水平高于对照组（P〈0.05）。观察组中急性发作期的血清L-33水平高于临床控制期（P〈0.05）,重度患者的血清L-33水平高于轻度和中度患者（P〈0.05）。观察组中急性发作期的血清IgE水平高于临床控制期（P〈0.05）,重度患者血清IgE水平高于轻度和中度患者（P〈0.05）。观察组中急性发作期的FEV1、FEV1/FVC、FEV1%pre均低于临床控制期（P〈0.05）,重度患者FEV1、FEV1/FVC、FEV1%pre均低于轻度和中度患者（P〈0.05）。观察组IL-33水平与IgE水平呈正相关（P〈0.05）,与FEV1、FEV1/FVC、FEV1%pre均呈负相关（P〈0.05）。结论 IL-33可能参与支气管哮喘的发生、发展,通过检测其水平变化有利于判断患者的肺功能及病情。

Level change and clinical significance analysis of serum IL-33 in patients with bronchial asthma

Objective To analyze the level change and clinical significance of serum IL-33 in patients with bronchial asthma. Methods Sixty-four patients with bronchial asthma admitted into our hospital were selected and classified into observation group,and another 60 health people for physical examination in our hospital in the same period were catego- rized into control group.Level of serum IL-33 in the two groups was tested and serum IgE and pulmonary function in- dex in observation group was determined respectively.Expression level of serum IL-33 in the two groups and IgE and pulmonary function index at different state of illness and severity in observation group was compared and analyzed respectively. Results The level of serum IL-33 in observation group was higher than that in control group（P〈0.05）.In observation group,level of serum IL-33 at acute attack stage was higher than that at clinical control period （P〈0.05）,level of serum IL-33 in critical condition patient was higher than that in mild or moderate condition patient respectively （P〈 0.05）,the level of serum IgE at acute attack stage group was higher than that at clinical control period（P〈0.05）,the level of serum IgE in critical condition patient was higher than that in mild and moderate condition patient respectively （P〈 0.05）,FEV 1,FEV1/FVC and FEV1% pre at acute attack stage was lower than that at clinical control period respectively （P〈0.05）,FEV1,FEV1/FVC and FEV1% pre in the critical condition patient was lower than that in the mild and moderate condition patient respectively （P〈0.05）.In observation group,the level of IL-33 had a positive correlation with IgE （P〈 0.05）,the level of IL-33 displayed negative correlation with FEV1,FEV1/FVC and FEV1% pre respectively （P〈0.05）. Conclusion IL-33 may get involved in the occurrence and development of bronchial asthma.IL-33 Level test is beneficial to make estimation on patient＇s pulmonary function and disease.