| ~（131）I－抗AFPMcAb－MMC“双弹头”导向药物对荷瘤裸鼠的放射免疫显像和治疗 |
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| 引用本文： | 李志革,刘康达,周德南,吴英德,贺海平,甘友全,黄秉琰. ~（131）I－抗AFPMcAb－MMC“双弹头”导向药物对荷瘤裸鼠的放射免疫显像和治疗[J]. 细胞与分子免疫学杂志, 1996, 0(3) |
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| 作者姓名： | 李志革 刘康达 周德南 吴英德 贺海平 甘友全 黄秉琰 |
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| 作者单位： | 广西医科大学附属肿瘤医院，上海医科大学肝病研究所 |
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| 基金项目： | 国家“八五”科技攻关资助 |
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| 摘 要： | 应用双弹头免疫导向治疗药物１３１Ｉ－抗ＡＦＰＭｃＡｂＭＭＣ进行荷人原发性肝癌棵鼠的体内放射免疫显像（ＲＩＩ）及放射免疫治疗（ＲＩＴ）研究。药物经腹腔给予后，第３ｄ即能选择性的定位于肿瘤；第１３ｄ抑瘤率高达８１．５％，远高于单纯１３１Ｉ－抗ＡＦＰＭｃＡｂ组和ＭＭＣ组（分别为２９．６％和１１．１％），提示该药物对人原发性肝癌细胞的亲和力好、杀伤力强，为其进入临床治疗提供了依据。
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| 关 键 词： | 单克隆抗体；放射免疫显像；放射免疫治疗 |
Radioimmunoimaging (RII) and Radioimmunotherapy (RIT) for Nude Mice Bearing Human Primary Hepatic Cancer Using ~(131)I-Anti-AFP McAb-MMC"Dual Warhead"Drug |
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| Li Zige,Liu Kangda,Zhuo Denan,et al.. Radioimmunoimaging (RII) and Radioimmunotherapy (RIT) for Nude Mice Bearing Human Primary Hepatic Cancer Using ~(131)I-Anti-AFP McAb-MMC"Dual Warhead"Drug[J]. Chinese journal of cellular and molecular immunology, 1996, 0(3) |
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| Authors: | Li Zige Liu Kangda Zhuo Denan et al. |
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| Abstract: | The study on radioimmunoimaging (RII) and radioimmunotherapy (RIT) for nude mice bearing human primary hepatic cancer(PHC) was preformed,using 131I-anti-AFP McAbMMC, which was a "Dual Warhead"RIT drug. After injection of 131I-anti-AFP McAb-MMC intraperitoneally(IP), selective accumulation was observed in tumor sites of nude mice bearing PHC on day 3 and the tumor growth inhibition rate was 81. 5% on day 13, higher than that in control groups.It suggests that this drug has a better affinity and stronger killing to human primary hepatic cancer cells. |
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| Keywords: | hepatoma monoclonal antibody radioimmunoimage radioimmunotherapy |
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