A category approach to predicting the developmental (neuro) toxicity of organotin compounds: The value of the zebrafish (Danio rerio) embryotoxicity test (ZET) |
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| Affiliation: | 1. Excet, Inc., Fort Detrick, Frederick, MD 21702-5010, USA;2. Environmental Health Program, US Army Center for Environmental Health Research, Fort Detrick, Frederick, MD 21702-5010, USA;3. ORISE Postdoctoral Fellow, Fort Detrick, Frederick, MD 21702-5010, USA;4. Pulmonary Health Program, US Army Center for Environmental Health Research, Fort Detrick, Frederick, MD 21702-5010, USA |
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| Abstract: | Zebrafish embryos were exposed to different organotin compounds during very early development (<100 h post fertilization). Morphology, histopathology and swimming activity (in a motor activity test) were the endpoints analyzed. DBTC was, by far, the most embryotoxic compound at all time points and endpoints studied. In fact, we observed a clear concordance between the effects observed in our zebrafish embryo model, and those observed with these compounds in full rodent in vivo studies. All organotin compounds classified as developmental (neuro) toxicants in vivo, were correctly classified in the present assay. Together, our results support the ZET model as a valuable tool for providing biological verification for a grouping and a read-across approach to developmental (neuro) toxicity. |
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| Keywords: | Zebrafish embryotoxicity test (ZET) Alternative model Organotins Developmental (neuro) toxicity Grouping Read across Biological verification |
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