| Expression of Vascular Endothelial Growth Factor in Hepatocellular Carcinoma and Its Relationship to Tumor Growth and Metastasis |
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| 作者姓名： | 郑世曦 武忠弼 阮幼冰 汤健 |
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| 作者单位： | ZHENG Shixi; WU Zhongbi; RUAN Youbing(Department of Ultrastructural Pathology，Research Center of Experimental Medicine，Tongji Medical University，Wuhan 430030)TANG Jian (Institute of Cardiovascular Research，Beijing Medical University，Beijing 100000) |
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| 摘 要： | Vascularendothelialgrowthfactor(VEGF)isanewlydiscoveredgrowthfactorwhichmayinducetumorangiogenesisll].Inthepresentstudy,immunohistochemistryandNorthernblotwereusedtoinvestigatetheVEGFexpressioninhepatocellularcarcilloma(HCC)withtheattempttounderstanditsrelationshiptothemetastasls.IMATERIALSANDMETHODS1.1TissueSamplesThespecimensinvestigatedwereobtainedfromZII)atientswithHCCoperatedattheaffiliatedhospitalsofouruniversity.Nineofthepatientsshowedclinicallymetastasiswithportalveintu…
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| 收稿时间： | 20 March 1997 |
Expression of vascular endothelial growth factor in hepatocellular carcinoma and its relationship to tumor growth and metastasis |
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| Zheng Shixi M. D., Ph.D.,Wu Zhongbi,Ruan Youbing,Tang Jian.Expression of Vascular Endothelial Growth Factor in Hepatocellular Carcinoma and Its Relationship to Tumor Growth and Metastasis[J].Journal of Zuazhong University of Science and Technology: Medical Edition,1998,18(1):10-12. |
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| Authors: | Zheng Shixi M D PhD Wu Zhongbi Ruan Youbing Tang Jian |
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| Institution: | (1) Department of Ultrastructural Pathology, Research Center of Experimental Medicine, Tongji Medical University, 430030 Wuhan;(2) Institute of Cardiovascular Research, Beijing Medical University, 100000 Beijing;(3) Present address: Shanghai Pharmaceutical Institute, China |
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| Abstract: | To understand the relationship between the expression of vasCular endothelial growth factor (VEGF) and the growth, metastasis of hepatocellular car cinoma (HCC), immunohistochemistry and Northern blot were used to investigate VEGF protein and mRNA in 21 cases of HCC with and without rnetastasis.VEGF protein was found in 8 of 9 cases with metastasis, whereas only in 4 of 12 cases without rnetastasis. The Positive rate of the former was significantly higher than that in the latter. VEGF mRNA was detectable in both carcinoma and its surrounding liver tissues, but its level in the former was 2 - 3 times higher than that in the latter. In carcinoma with metastasis, the mRNA level was 5-6 times higher than that without metastasis. It is concluded that VEGF Is closely related to the growth of HCC as well as its metastasis and it might be a useful indicator for the metastatic potential of HCC. |
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| Keywords: | vascular endothelial growth factor hepatocellular carcinoma metastasis |
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