沉香对肠平滑肌的药理作用

本文报道中药沉香的水煮液和水煮酒沉液能抑制离体豚鼠回肠的自主收缩,对抗组织胺、乙酰胆碱引起的痉挛性收缩;对整体动物能使新斯的明引起的小鼠肠推进运动减慢,呈现肠平滑肌解痉作用;使麻醉猫注射乙酰胆碱后肠管收缩幅度减少,蠕动减慢。实验结果表明,这些作用可能是沉香对肠平滑肌的直接作用。

Pharmacological Actions of Lignum Aquilariae Resinatum (Aquilaria agallocha Roxb.) on the Smooth Muscle of Intestines

The aqueous solution of Lignum Aquilariae Resinatum (Aquilaria agallocha) can inhibit the automatic contraction of isolated ileum of guinea-pigs, and the aqueous solution purified by precipitation with 80% alcohol can antagonize its spasmodic contraction caused by histami and acetylcholine. Such solution can slow down the advance movement of mouse intestine in situ caused by neostigmine and relieve the spasm of the smooth muscle of intestine. In addition, the purified aqueous solution mentioned above can decrease the intestinal contraction range in anesthetized cat caused by injection of acetylcholine. These experimental results show that Aquilaria agallocha acts against the smooth muscle of intestine directly.