Leptin resistance does not induce hyperphagia in the rat |
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Authors: | Takashi Higuchi Akiko Mizuno Kazumi Narita Toru Ichimaru Takuya Murata |
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Institution: | (1) Department of Integrative Physiology, Faculty of Biomedical Sciences, University of Fukui, Matsuoka, Eiheiji-cho, Fukui 910-1193, Japan |
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Abstract: | Leptin has been thought to work as a mediator for body weight control by inhibiting food intake. Leptin, however, cannot prevent
obesity induced by a high-fat diet (HFD) probably because of leptin resistance. We investigated daily feeding and weight gain
when ordinary chow (OC) was changed to a HFD in male rats. Food intake, by weight, significantly increased the next day, but
gradually decreased until at 20 days the HFD intake contained the same calories as consumed by the OC-fed control rats. The
reduction in food intake occurred only during the night without change of preference for the HFD, even after leptin resistance
had developed. Nonetheless, the HFD-fed rats gained more weight than the controls. From the present experiment, it is concluded
that leptin resistance does not induce hyperphagia, and suggested that body weight is not regulated to be constant. |
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