张镜人教授治疗多发性骨髓瘤的经验

多发性骨髓瘤是一种浆细胞系恶性肿瘤，以骨髓中浆细胞恶性克隆增生，血清或尿液中出现单克隆免疫球蛋白或其成分（M蛋白），正常免疫蛋白受到抑制以及广泛溶骨病变和（或）骨质疏松为特征，引起骨折和骨髓功能衰竭，产生一系列临床症状，预后差［1］。张镜人老中医对多发性骨髓瘤的中医治疗有着深厚造诣，认为其病机乃肝肾气阴亏虚为本，外邪夹瘀痰阻络为标，治疗上扶正与祛邪并重，虚症以益气养阴、补益肝肾为主，实证以清热散瘀、凉血止血为主，有一定疗效。该文从中医病因、病机、治法、方药等角度对张教授治疗多发性骨髓瘤的临床心得进行探讨，并举验案1则。

Experience of Professor Zhang Jingren on Curing Multiple Myeloma

Multiple myeloma (MM) is a debilitating malignancy that is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia, which is featured by proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraprotein (M protein). It would cause fracture and bone function failure with a series of clinical symptoms with bad prognosis. The notable Chinese medicine doctor Profosser zhang Jingren has enriched experience and understanding on treating MM, who believes the disease mechanism is due the deficiency of liver-kidney yin, manifested with stasis and phlegm obstruction in channels. The treatment shall pay attention to both supporting right and dispelling evil. Benefiting qi and nourishing yin is applied to treat deficiency syndrome as well as tonifying liver and kidney. To treat excess syndrome, clearing heat and dispelling stasis, cooling blood are applied. This paper explores the TCM cause, mechanism, rules, formula of MM from the clinical experience of professor Zhang Jingren,