Isolation and characterization of impurities present in 8-chlorotheophylline |
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Authors: | Desai Sonal Patel Archita Gabhe S Y |
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Affiliation: | C. U. Shah College of Pharmacy, S. N. D. T. Women's University, Sir Vithaldas Vidya Vihar, Juhu Tara Road, Santacruz (W), Mumbai - 400 049, India. |
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Abstract: | A simple isocratic reversed phase high performance liquid chromatography was used to separate three impurities present in the sample of 8-chlorotheophylline. LC-MS was used for the characterization of impurities. Based on mass spectral data, the structures of these impurities were characterized as 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione (impurity I), 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione (impurity II) and isomer of 8-chloro-1,3-dimethyl-2,6(3H,1H)-purinedione (impurity III). |
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Keywords: | 8-Chlorotheophylline impurity LC-MS reversed phase HPLC theophylline |
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