| Abstract: | A survey of boys with hypercholesterolemia, hypertriglyceridemia, hypo-alpha-cholesterolemia, a combination of hypo-alpha-cholesterolemia and hypertriglyceridemia, and hyperalphacholesterolemia, and control subjects from two Moscow districts demonstrated significantly elevated plasma testosterone and estradiol values in boys with hypo-alphacholesterolemia. Increased estradiol was also found in boys with hypercholesterolemia and hyperalphacholesterolemia. An inverse relationship between plasma testosterone level and high density lipoprotein (HDLP) cholesterol, and a direct relationship between the estradiol/testosterone ratio and HDLP cholesterol were established. Individuals with high testosterone and estradiol levels had elevated systolic arterial BP, and those with high systolic arterial BP showed increased testosterone and estradiol levels. It is suggested that reduced high density lipoprotein cholesterol and elevated systolic arterial BP in boys with increased testosterone levels may be regarded as early signs of developing hypo-alphacholesterolemia in combination with arterial hypertension. |
