Cold-induced vasospasm in patients with fibromyalgia and chronic low back pain in comparison to healthy subjects |
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Authors: | E. Lapossy P. Gasser P. Hrycaj B. Dubler W. Samborski Prof. Dr. W. Muller |
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Affiliation: | (1) Medical Outpatient Department of the University, Cantonal Hospital, Basle, Switzerland;(2) Hochrhein-Institute for Research and Prevention of Rheumatic Diseases, Bergseestrasse 61, D-79713 Bad Säckingen, Germany |
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Abstract: | Summary Using capillary videomicroscopy of the nail fold, the frequency of cold-induced vasospasm and capillary hemodynamic parameters were studied after application of cold in 50 patients with primary fibromyalgia, 50 patients with chronic low back pain, and 50 healthy controls. Cold-induced vasospasm was detected in 38% of the patients with fibromyalgia. In this group it was significantly more frequent than in the patients with chronic low back pain (20%, p<0.05) and healthy subjects (8%, p<0.001). In the fibromyalgia group, the magnitude of vasospasm as measured by the capillary blood flow deceleration after cold application correlated negatively with the pain intensity as measured by pain score (r=–0.3839, p<0.01). No differences in clinical appearance were found between patients with and without cold-induced vasospasm in both the fibromyalgia and low back pain group. |
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Keywords: | Capillary Videomicroscopy Vasospasm Cold Provocation Test Fibromyalgia Low Back Pain |
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