| 皮肤撕脱伤后丙二醛含量变化及其意义 |
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| 引用本文： | 郭树忠,鲁开化,张琳西.皮肤撕脱伤后丙二醛含量变化及其意义[J].中国美容医学,2001,10(6):477-479. |
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| 作者姓名： | 郭树忠 鲁开化 张琳西 |
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| 作者单位： | 第四军医大学西京医院整形外科中心,西安710032 |
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| 基金项目： | 国家自然科学基金资助项目 (39470 70 5 ) |
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| 摘 要： | 目的：研究氧自由基在皮肤撕脱伤组织继发坏死中的作用。方法：用自行研制的皮肤撕脱伤模型机复制猪后肢皮肤撕脱伤模型，分别测定了正常、伤后1、2、4、8、12、24小时血清、撕脱皮肤和皮下组织中的丙二(MDA)含量，绘制了其时间的变化曲线。结果：皮肤撕脱伤后24小时内组织和血清中丙二醛含量均显著升高，其变化有一定的规律。结论：皮肤撕脱伤组织中脂质过氧化反应增强，推测自由基在撕脱皮瓣继发坏死中能发挥重要的作用。
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| 关 键 词： | 皮肤撕脱伤 丙二醛 自由基 |
| 文章编号： | 1008-6455(2001)06-0477-03 |
| 修稿时间： | 2001年3月29日 |
INVESTIGATE OF MDA IN SERUM AND AVULSED TISSUE AFTER SKIN AVULSION INJURY |
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| GUO Shu,zhong,LU Kai,hua,ZHANG Lin,xi.INVESTIGATE OF MDA IN SERUM AND AVULSED TISSUE AFTER SKIN AVULSION INJURY[J].Chinese Journal of Aesthetic Medicine,2001,10(6):477-479. |
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| Authors: | GUO Shu zhong LU Kai hua ZHANG Lin xi |
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| Institution: | GUO Shu zhong LU Kai hua ZHANG Lin xi Department of Plastic Surgery,Xijing Hospital,The Fourth Military Medical University, |
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| Abstract: | Objective:To investigate the role of the free radicals in the necrosis of avulsed tissue after skin avulsion injury Methods:To mimicked traffic accident,a machine was developed An avulsion injury model was created in hind leg of pig The malanyldialehyde(MDA)in serum and avlused tissue was measured 1,2,4,8,12,24 hours after trauma Results:The MDA in serum and avlused tissue increased constantly after injury Conclusion:The free radicals may play a very important role in the necrosis of avulsed tissue |
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| Keywords: | Skin avulsion injury MDA Free radicals |
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