头孢吡肟与头孢他啶治疗中性粒细胞缺乏伴发热的疗效

目的　分析头孢吡肟与头孢他啶治疗血液系统肿瘤患者中性粒细胞缺乏伴发热的疗效和副反应。　方法　 10 6例中性粒细胞缺乏伴发热的血液系统肿瘤患者 ,分别用头孢吡肟或头孢他啶为主的经验性治疗 ,对比其临床疗效、病原菌清除和副反应。　结果　两组临床有效率分别为 6 7.2 %和 5 6 .9% ,平均退热时间分别为 2 .97± 0 .98d和 3.36± 0 .87d。病原菌清除率分别为 5 6 .3%和 5 7.1%。　结论　头孢吡肟和头孢他啶可作为经验性治疗中性粒细胞低下伴发热的血液系统肿瘤患者的理想药物 ,副反应轻 ,耐受性好。

Effect of cefepime and ceftazidime on febrile neutropenic patients with tumor of blood system

Objective To explore the curative rate and side reaction of cefepime(CEF) and ceftazidime(CEZ) on febrile neutropenic patients with tumor of blood system. Methods One hundred and six patients with febrile neutroperia and tumor of blood system were divided into two groups,and received either cefepime and ceftazidime. The clinical and bacteriological efficacy as well as the side reaction of the two groups were compared. Results There was no statistical significant difference in clinical efficacy between the two group ( 67.2 % in CEF vs 56.9% in CEZ), P>0.05. The average time of defebrile was 2.97+0.98 days and 3.36+ 0.87 days,respectively (P>0.05). The bacteriological effective rate was 56.3% and 57.1%, respectively. Conclusion Cefepime and ceftazidime are ideal drugs for empirical therapy of febrile neutropenic patients with tumor of blood system. The side reaction of the two drugs are light.