Glutathione-S-transferase-1 and interleukin-1beta gene polymorphisms in Japanese patients with Parkinson's disease. |
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Authors: | Masataka Nishimura Sadako Kuno Ryuji Kaji Katsuhito Yasuno Hideshi Kawakami |
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Institution: | Clinical Research Center, Konan Hospital, Shiga, Japan. ma-nishi@vmail.plala.or.jp |
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Abstract: | We studied genetic polymorphisms in the glutathione-S-transferase-1 (GST-1) gene region and the interleukin-1beta (IL-1beta) promoter region in patients with Parkinson's disease (PD, n = 361), as well as controls (n = 257). Although we have confirmed the previous results, in a larger sample, that the IL-1beta genotype has affected the age at onset of PD patients, no contribution of the GST-1 gene polymorphism was observed in the allele frequency or the onset age of the disease in Japanese persons. |
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Keywords: | glutathione‐S‐transferase‐1 (GST‐1) interleukin‐1β (IL‐1β) Parkinson's disease (PD) polymorphism age at onset |
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