国产与进口乙肝基因疫苗阻断HBV母婴传播效果研究

目的对国产和进口CHO乙肝基因工程疫苗阻断HBV母婴传播效果进行研究.方法分别用长春生物制品研究所和法国巴斯德公司生产的20ug/剂CHO乙肝基因工程疫苗,对HBsAg和HBeAg阳性母亲的健康新生儿进行免疫,并定期随访检测其血清HBsAg和抗-HBs情况,了解阻断HBV母婴传播效果.各组观察时间≥9个月者分别为33例和24例.结果免疫保护率分别为79.2%和51.7%(P＜0.05);T9抗-HBs阳转率最高,分别为81.0%和68.4%(P＞0.05);T12抗体水平达高峰分别为208.5和379.3mIU(P＜0.05).结论国产CHO乙肝基因工程疫苗具有良好的保护性,阻断HBV母婴传播的效果较进口疫苗好;但进口疫苗诱导产生的抗体水平高于国产疫苗.

Studies on Interruption of Perinatal Transmission of HBV by Domestie and Foreign Hepatitis B Vaccine

Objective To Study the interruption effect of perinatal transmission of HBV by domestile and foreign Hepatitis B vaccine.Methods To infants of HBsAg and HBeAg both positive mothers were vaccinated with Chinese hamster ovary cell (CHO) recombinant hepatitis B vaccine (20ug/dose,by Changchun Institute of Biological Products and Paster Company of France,at 0,first,6th month.All the babies were followed up from 9th to 24th month.Results The results showed that the protective rates were 79 2% and 51 7%( P <0 05),respectively.The positive rates of Anti-HBs were 81 0% and 68 4%( P >0 05) at 9 months, respectively.The geometric mean titers of Anti-HBs were 208 5 m IU and 379 3 m IU( P <0 01)at 12 months,respectively.Conclusions The initial results revealed Changchun CHO recombinant vaccine had higher protective rates than Paster vaccine.But the geometric mean titers of Anti-HBs was lower than Paster vaccine.