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Kinetic evaluation of platelet monoamine oxidase following relaxation in chronic anxiety
Authors:P M Kralik  B T Ho  R J Mathew  J L Claghorn
Abstract:ABSTRACT - The effect of relaxation training, utilizing EMG biofeedback, on platelet monoamine oxidase (MAO) activity was examined in patients with a history of chronic anxiety. Anxiety scores and MAO activity were significantly lowered after 4 weeks of therapy. Kinetic studies, using phenylethylamine as substrate, indicated a significant increase of the Km constant while the V. showed no significant or consistent variation. It is thought that this phenomenon represents an adaptive response by the individual to maintain a homeostatic level of the biogenic amines.
Keywords:Anxiety  relaxation  biofeedback  monoamine oxidase (MAO)  platelets  tryptamine  phenylethylamine  enzyme kinetics
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