Synthesis and CNS Activity of N,N-Disubstituted 1-(Aminomethyl)-5-alkyl-3-(aryloxyacetylhydrazono)indolin-2-ones

Isatin and 5-methylisatin were condensed with various aryloxyacetylhydrazides to furnish the 3-(aryloxyacetylhydrazono)-5-alkylindolin-2-ones 1–4 . When 1–4 were subjected to Mannich reaction, the N,N-disubstituted 1-(aminomethyl)-5-alkyl-3-(aryloxyacetylhydrazono)indolin-2-ones 5–8 were obtained. The compounds were CNS active and relatively non-toxic (albino mice).