Untersuchungen zur Eiweißbindung von Arzneistoffen durch kontinuierliche Ultrafiltration, 4. Mitt. |
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| Authors: | Klaus Rehse Madeleine Rothe |
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| Abstract: | Protein Binding Determined by Continuous Ultrafiltration, IV: Protein Bindung of Anticoagulant 1,2-Benzoxathiines The binding of three 1,2-benzoxathiines to human serum albumin has been investigated. The compound 3-(3-oxo-1-phenylbutyl)-1,2-benzoxathiin-4(3H)-one 2,2-dioxide (1) and its 4-methoxyphenyl analog 2 are bound in the same order of magnitude as warfarin. The binding of the 3,4-dichlorophenyl analog 3 is about tenfold stronger than that of usual anticoagulants. |
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