| 二(2-吡啶基-N-氧化物)二硫化物对K562细胞增殖的抑制作用 |
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| 引用本文： | 王彩霞,张兴荣. 二(2-吡啶基-N-氧化物)二硫化物对K562细胞增殖的抑制作用[J]. 西北药学杂志, 2012, 27(2): 138-140 |
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| 作者姓名： | 王彩霞 张兴荣 |
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| 作者单位： | 1. 甘肃省兰州市第一人民医院,兰州,730050
2. 甘肃省靖远煤业集团公司总医院,白银,730900 |
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| 摘 要： | 目的研究二(2-吡啶基-N-氧化物)二硫化物(L)对K562细胞增殖的影响。方法应用MTT比色法检测L对K562细胞增殖的影响;应用透射电镜检测L对K562细胞凋亡形态学的影响;应用流式细胞仪检测L对K562细胞周期的影响。结果 L可抑制K562细胞的增殖,呈现浓度依赖性;L可使K562细胞呈现凋亡形态学特征;L可使K562细胞周期发生阻滞。结论 L在体外具有抑制K562细胞增殖的作用。
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| 关 键 词： | 二(2-吡啶基-N-氧化物)二硫化物 K562细胞 增殖 |
Bis(2-pyridyl-N-oxide) disulphide inhibits the proliferation of K562 cells in vitro |
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| WANG Caixia , ZHANG Xingrong. Bis(2-pyridyl-N-oxide) disulphide inhibits the proliferation of K562 cells in vitro[J]. Northwest Pharmaceutical Journal, 2012, 27(2): 138-140 |
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| Authors: | WANG Caixia ZHANG Xingrong |
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| Affiliation: | 1.Lanzhou First People’s Hospital,Lanzhou 730050,China;2.Jingyuan Coal Mining Hospital,Baiyin 730900,China) |
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| Abstract: | Objective To study the inhibitory effects of bis(2-pyridyl-N-oxide) disulphide on K562 cells.Methods Cell viability was determined by MTT assay.Intracellular morphology was observed by transmission electron microscopy.Cell cycle was detected by flow cytometry.Results Bis(2-pyridyl-N-oxide)disulphide inhibited the proliferation of K562 cells in a concentration-dependent manner.Bis(2-pyridyl-N-oxide)disulphide induced the apoptotic morphology and an arrest of cell cycle in K562 cells.Conclusion Bis(2-pyridyl-N-oxide)disulphide inhibits the proliferation of K562 Cells in vitro. |
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| Keywords: | bis(2-pyridyl-N-oxide)disulphide K562 cells proliferation |
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