| 甘精胰岛素联合口服降糖药治疗Ⅱ型糖尿病的疗效观察 |
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| 引用本文： | 杨颖,邓晨昕,高凌,张黎明,马计,肖婧,田源. 甘精胰岛素联合口服降糖药治疗Ⅱ型糖尿病的疗效观察[J]. 西部医学, 2012, 24(2): 308-309 |
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| 作者姓名： | 杨颖 邓晨昕 高凌 张黎明 马计 肖婧 田源 |
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| 作者单位： | 襄阳市中心医院内分泌科,湖北襄阳,441021 |
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| 摘 要： | 目的研究每日2次预混胰岛素治疗的Ⅱ型糖尿病患者转为每日注射一次甘精胰岛素联合OAD(口服降糖药)治疗的有效性和安全性。方法 68例每日注射2次预混胰岛素(联合或不联合口服降糖药)血糖控制欠佳的Ⅱ型糖尿病患者换用每日注射一次甘精胰岛素联合OAD治疗,在治疗第0周及12周分别记录空腹血糖、餐后2小时血糖、HbA1c(糖化血红蛋白)及胰岛素用量。结果治疗12周后空腹血糖、餐后2小时血糖、HbA1c均较基线水平显著下降。低血糖事件共发生5例次。结论预混胰岛素治疗血糖控制欠佳的Ⅱ型糖尿病患者转为每日注射一次甘精胰岛素联合OAD治疗能有效并安全的控制血糖。
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| 关 键 词： | 糖尿病 甘精胰岛素 |
Therapeutic effect observation of patients with type 2 diabetes inadequately controlled switch from premixed insulin regimen to glargine plus oral antidiabetic drugs |
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| Affiliation: | YANG Ying,DENG Chen-xin,GAO Ling,et al(Department of Endocrinology,Xiangyang Central Hospital,Xiangyang 441021,Hubei,China) |
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| Abstract: | Objective To study the efficacy and safety of insulin glargine plus oral antidiabetic drugs(OAD) in T2DM patients previously treated with premixed insulin.Methods 68 Type 2 diabetes mellitus patients taking premixed insulin were eligible to switch to glargine plus OAD.Fasting blood glucose(FBG),2-h post prandial Blood glucose(2-h PPBG),glycosylated haemoglobin(HbA1c),insulin dosage were measured at the start and after a 12-week observation period.Results FBG,2-hPPBG and HbA1c improved significantly from start to end-point respectively.Insulin dosage were similar between the start and end of the observation period.Five episodes of hypoglycaemia were reported.Conclusion Type 2 diabetic patients treated with twice-daily injection of premixed 30R insulin can be effectively and safely switched to basal insulin plus OAD. |
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| Keywords: | Diabetes mellitus Insulin glargine |
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