| 急性脑血管痉挛大鼠血浆及脑组织内皮素—1含量动态变化研究 |
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| 引用本文： | 孙保亮,戴小牛.急性脑血管痉挛大鼠血浆及脑组织内皮素—1含量动态变化研究[J].泰山医学院学报,2000,21(1):11-13. |
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| 作者姓名： | 孙保亮 戴小牛 |
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| 作者单位： | 泰山医学院附属医院微循环研究所!山东泰安271000(孙保亮，夏作理，杨明峰，邱平明)，南京铁道医学院生理学教研室!江苏南京210000(戴小牛) |
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| 摘 要： | 目的 探讨内皮素－１（ＥＴ１）在蛛网膜下腔出血（ＳＡＨ）后急性脑血管痉挛（ＣＶＳ）及其因性缶害中的作用。方法 应用大鼠ＳＡＨ模型，以假手术组为对照，检测２４ｈ内局部脑血流量，血浆及脑组织ＥＴ１含量的动态改变，同时于手术前后测量基底动脉（ＢＡ）管径。结果 ＳＡ后２４内ｒＣＢＦ迅速而持续降低，血浆及脑组织ＥＴＩ浓度显著增加。ＳＡＨ后ＢＡ明显痉挛。结论 血浆及脑组织ＥＴ１增加在ＳＡＨ后急性ＣＶＳ及其脑缺
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| 关 键 词： | 蛛网膜下腔出血 脑血管痉挛 内皮素 |
Dynamic changes of endothelin-1 levels in plasma and brain tissue during acute cerebral vasospasm following subarachnoid hemorrhagein rats |
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| SUN Bao liang ,XIA Zuo li ,YANG Ming feng ,DAI Xiao niu ,QIU Ping ming.Dynamic changes of endothelin-1 levels in plasma and brain tissue during acute cerebral vasospasm following subarachnoid hemorrhagein rats[J].Journal of Taishan Medical College,2000,21(1):11-13. |
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| Authors: | SUN Bao liang XIA Zuo li YANG Ming feng DAI Xiao niu QIU Ping ming |
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| Institution: | SUN Bao liang 1,XIA Zuo li 1,YANG Ming feng 1,DAI Xiao niu 2,QIU Ping ming 1 |
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| Abstract: | Objective: To investigate the possible roles of endothelin 1(ET1)in the development of acute cerebral vasospasm(CVS) and related brain ischemicdamage following subarachnoid hemorrhage(SAH). Methods: SAH models of Wistar rats were used and animals were divided into SAH group and sham operated group. Diameter of basilar artery(BA) was measured before and after operation. Dynamic changes of regional cerebral blood flow(rCBF), and ET1 concentrations in both intracranial plasma and brain tissue were observed within 24 hours after SAH. Results: Within 24 hours after induction of SAH, rCBF decreased rapidly and persistently while ET1 concentrations increased obviously. Spasm of BA occurred 30 minutes after SAH. Conclusion: Increase of ET1 concentrations in plasma and brain tissue plays an important important role in the development of acute CVS and related brain ischemic damage after SAH. |
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| Keywords: | subarachnoid hemorrhage cerebral vasospasm endothelins |
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