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Early presentation of osteonecrosis in acute lymphoblastic leukemia: Two children from the Nordic and Baltic cohort |
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| Authors: | Signe Sloth Mogensen Arja Harila‐Saari Thomas Leth Frandsen Päivi Lähteenmäki Anders Castor Ia Kohonen Kjeld Schmiegelow Outi Mäkitie |
| Affiliation: | 1. Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark;2. Department of Pediatric Oncology, Astrid Lindgren Children's Hospital, Karolinska Hospital, Stockholm, Sweden;3. Department of Pediatric and Adolecent Medicine, Turku University Hospital and University of Turku, Finland;4. Department of Pediatric Oncology, Skane University Hospital, Lund, Sweden;5. Medical Imaging of Southwest Finland, University of Turku, Turku, Finland;6. Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden;7. Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden;8. Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland |
| Abstract: | Osteonecrosis (ON) is usually considered treatment related in patients with acute lymphoblastic leukemia (ALL). We report two patients with presentation of ON at the time of ALL diagnosis. Both were females and diagnosed with ALL at age 8 and 14 years. In the latter, some symptoms and radiologically verified ON in both knees were still present after the end of ALL therapy. No pediatric patients have previously been reported with ON presenting before initiation of ALL therapy. |
| Keywords: | acute lymphoblastic leukemia children early manifestation osteonecrosis skeletal complication |