Clinical case series of pediatric hepatic angiosarcoma |
| |
| Authors: | Kalee L. Grassia Caitlin M. Peterman Ionela Iacobas Judith F. Margolin Ewa Bien Bhavna Padhye Rebecka L. Meyers Denise M. Adams |
| |
| Affiliation: | 1. University of Cincinnati College of Medicine, Cincinnati, Ohio;2. Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio;3. Tufts University School of Medicine, Boston, Massachusetts;4. Department of Dermatology, Harvard Medical School, Boston Children's Hospital, Boston, Massachusetts;5. Division of Hematology/Oncology, Baylor College of Medicine, Houston, Texas;6. Department of Pediatrics, Hematology, and Oncology, Medical University of Gdansk, Gdansk, Poland;7. Department of Oncology, The Children's Hospital at Westmead, Sydney, Australia;8. Department of Surgery, University of Utah Health Center, Salt Lake City, Utah;9. Department of Hematology/Oncology, Harvard Medical School, Boston Children's Hospital, Boston, Massachusetts |
| |
| Abstract: | Hepatic angiosarcoma is a rare, aggressive, malignant neoplasm with fewer than 50 cases reported in children. Prognosis is poor, with a minority surviving beyond 2 years after diagnosis. We report eight cases of pediatric hepatic angiosarcoma, diagnosed at a mean age of 3 years. Seven were initially diagnosed with an infantile hepatic hemangioendothelioma (IHHE) or hemangioma and the eighth with a “vascular tumor.” Two patients, who received liver transplant, survived. We suggest hepatic hemangiomas can rarely transform into angiosarcomas and a subset of IHHEs (Type II) are actually a low‐grade form of angiosarcoma rather than a benign lesion. |
| |
| Keywords: | hemangioendothelioma hepatic angiosarcoma hepatic hemangioma infantile hemangioma |
|
|
