Comparative toxicity study of 2,4,6-trinitrophenol (picric acid) in newborn and young rats |
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Authors: | Takahashi Mika Ogata Hidehiro Izumi Hiroyuki Yamashita Kotaro Takechi Masato Hirata-Koizumi Mutsuko Kamata Eiichi Hasegawa Ryuichi Ema Makoto |
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Affiliation: | National Institute of Health Sciences, Tokyo 158-8501, Japan. |
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Abstract: | The toxicity of oral 2,4,6-trinitrophenol (TNP) was determined in newborn rats, and compared with that in young rats. In newborn rats, males and females were given TNP at 0, 16.3, 81.4 or 407 mg/kg per day on postnatal days (PND) 4-17 for the dose-finding study, and at 0, 4.1, 16.3 or 65.1 mg/kg per day on PND 4-21 for the main study. Deaths, lower body weight (BW) and behavioral changes were found at 81.4 and 407 mg/kg per day in the dose-finding study, and lower BW was observed in males at 65.1 mg/kg per day during the dosing period of the main study. In young rats, 5-week-old males and females were given TNP at 0, 20, 100 or 500 mg/kg per day for 14 days as the dose-finding study and at 0, 4, 20 or 100 mg/kg per day for 28 days as the main study. Deaths were observed at 500 mg/kg per day in the dose-finding study. Deaths or changes in BW were not found at 100 mg/kg per day or less. At 100 mg/kg per day, hemolytic anemia and testicular toxicity were found. In conclusion, toxicity profiles induced by TNP were markedly different between newborn and young rats. |
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Keywords: | 2 4 6-trinitrophenol newborn rats picric acid repeated-dose toxicity young rats |
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