托吡酯对癫痫患儿血清瘦素、骨钙蛋白及血钙的影响

目的探讨托吡酯对癫痫患儿血清瘦素、骨钙蛋白及血钙的影响。方法选取35例癫痫患儿为托吡酯组，同时选取35例健康小儿为正常对照组。托吡酯组予托吡酯单药治疗，检测托吡酯组治疗前及托吡酯组治疗半年后血清瘦素、骨钙蛋白及血钙水平并与对照组比较。结果治疗后，托吡酯组患儿的血清瘦素、骨钙蛋白及血钙均较治疗前明显下降（P＜ 0.05），且明显低于正常对照组（P＜ 0.05）。结论托吡酯可降低癫痫患儿血清瘦素、骨钙蛋白及血钙水平，抑制体质量的增长和骨的形成，故采用托吡酯治疗的同时，应同时补钙。

Impact of Topiramate on Serum Leptin,Osteocalcin and Blood Calcium in Pediatric Patients with Epilepsy

Objective]To explore the effect of topiramate（TPM）on serum leptin,osteocalcin and blood calcium in pediatric patients with epilepsy.Methods]A total of 35 pediatric patients with epilepsy were select-ed as TPM group.Meanwhile,35 healthy children were selected as normal control group.TPM group was treated with TPM alone.Serum leptin,osteocalcin and blood calcium in TPM group before and half a year af-ter treatment were measured and compared with those in control group.Results]Compared with before treat-ment,serum leptin,osteocalcin and blood calcium in TPM group after treatment were decreased obviously（P〈 0.05）,and lower than those in control group（P〈 0.05）.Conclusion]TPM can decrease serum leptin,os-teocalcin and blood calcium,and inhibit the increment of body weight and bone formation in pediatric patients with epilepsy.Therefore,TPM therapy should be combined with calcium supplement simultaneously.