甲基强的松龙冲击治疗儿童睡眠中癫痫性电持续状态的临床疗效观察

目的 探讨甲基强的松龙冲击治疗儿童睡眠中癫痫性电持续状态（ES ES ）的疗效。方法 选取2007年5月至2013年4月在本院儿科门诊就诊的伴ES ES的癫痫患儿31例，随机分为治疗组和对照组，治疗组16例，对照组15例。治疗组给予甲基强的松龙冲击序贯泼尼松口服，并给予常规抗癫痫药物丙戊酸钠治疗。对照组给予丙戊酸钠口服治疗。随访6个月，并对结果进行分析。结果 治疗组16例患儿，有效12例，有效率75％，药物不良反应率25．7％，对照组15例，有效率46．6％，药物不良反应率22．8％。两组治疗有效率对比有显著性差异（P ＜0．05），两组药物不良反应率对比无显著性差异（P ＞0．05）。结论 甲基强的松龙冲击疗法对比常规抗癫痫药物，在治疗 ESES患儿上，效果明显，但须注意激素对患儿的不良反应。

Observation on Clinical Efficacy of Methylprednisolone Pulse Therapy for Children with Electrical Status Epilepticus in Sleep

Objective] To explore the efficacy of methylprednisolone pulse therapy for children with electrical status epilepticus in sleep（ESES） .Methods]A total of 31 pediatric patients with epilepsy and ESES in pediatric outpatient de‐partment of our hospital from May 2007 to April 2013 were chosen and randomly divided into treatment group（ n=16） and control group（ n=15） .The treatment group was given methylprednisolone pulse therapy ,oral prednisone and con‐ventional antiepileptics valproate .The control group was only given oral valproate .All patients were followed up for 6 months .The results were analyzed .Results]In treatment group ,12 patients were effective ,and the efficiency was 75% ,and the incidence of drug adverse reaction was 25 .7% .In control group ,15 patients were effective ,and the effi‐ciency was 46 .6% ,and the incidence of drug adverse reaction was 22 .8% .There was significant difference in the effi‐ciency between two groups（ P〈0 .05） ,but there was no significant difference in the incidence of drug adverse reaction rate between two groups（ P〉0 .05） .Conclusion]Compared with conventional antiepileptics ,methylprednisolone pulse therapy for pediatric patients with ESES has obvious efficacy ,but the side effect of hormone therapy on pediatric patients should be paid attention .