| 米非司酮对大鼠黄体和子宫内膜纤溶酶原激活因子的调节作用 |
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| 引用本文： | 熊忠明,朱长虹,肖惠珠.米非司酮对大鼠黄体和子宫内膜纤溶酶原激活因子的调节作用[J].华中科技大学学报(医学版),2000,29(5):402-404. |
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| 作者姓名： | 熊忠明 朱长虹 肖惠珠 |
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| 作者单位： | 同济医科大学计划生育研究所，武汉 430030 |
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| 摘 要： | 采用纤维蛋白铺盖和放射免疫方法研究了米非司酮(RU486)对培养颗粒细胞及黄体细胞纤溶酶原激活因子(包括组织型tPA和尿激酶型uPA)的作用。结果示RU486能明显拮抗入绒毛膜促性腺激素(hCG)促进颗粒细胞tPA活性及孕酮分泌的作用。RU486和PGF2α能明显促进黄体细胞tPA分泌，但孕酮产生明显被抑制。用组织学培养的方法，结果表明，RU486能刺激妊娠子宫内膜tPA和uPA分泌。这些结果表明RU486的抗生育作用部分能通过PA起到抗排卵、溶黄体及抗早孕的作用。
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| 关 键 词： | 纤溶酶原激活因子 孕酮 米非司酮 前列腺素 |
| 修稿时间： | 2000年6月30日 |
Effect of Mifepristone on Production of Pl asminogen Activators and Progesterone in Rat Reproductive System |
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| Xiong Zhongming,ZHU Changhong,Xiao Huizhu.Effect of Mifepristone on Production of Pl asminogen Activators and Progesterone in Rat Reproductive System[J].Journal of Huazhong University of Science and Technology(Health Sciences),2000,29(5):402-404. |
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| Authors: | Xiong Zhongming ZHU Changhong Xiao Huizhu |
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| Abstract: | The effects of mifepristone (RU486) on the productions of plasminogen activator and progesterone in rat granulosa cells and luteal cells were studied by fibrin overlay method and radioimmunoassay method. The results showed that RU486 could significantly antagonize tPA activity and progesterone production enhanced by human chorionic gonadotropin (hCG). Secretion of tPA from luteal cells was significantly promoted by RU486 with or without prostaglandin F2a (PGF2α), but progesterone production in luteal cells was markedly inhibited with the same treatment. With method of tissue culture, the results showed that RU486 was capable of stimulating tPA and urokinase (uPA) activity in endometrium of pregnant rats. These findings indicated that antifertility of RU486 might be partly mediated through plasminogen activator-plasminogen activator inhibitor system. |
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| Keywords: | plasminogen activator progesterone mifepristone prostaglandin |
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