| 脊柱化脓性感染动物模型的建立及应用进展 |
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| 引用本文： | 李江笔,王永杰,那士博,吴宏,刘军,纪雪,公伟权,刘理迪,吕振山,张绍昆. 脊柱化脓性感染动物模型的建立及应用进展[J]. 中国骨与关节杂志, 2020, 0(1): 75-79 |
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| 作者姓名： | 李江笔 王永杰 那士博 吴宏 刘军 纪雪 公伟权 刘理迪 吕振山 张绍昆 |
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| 作者单位： | 吉林大学第一医院脊柱外科;军事科学院军事医学研究院军事兽医研究所吉林省人兽共患病预防与控制重点实验室 |
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| 摘 要： | 手术部位感染是脊柱手术后常见且非常严重的并发症,严重影响患者的身体健康。尽管手术操作无菌细致,及时给予适当的全身抗生素,但手术部位感染率仍然很高[1-2]。据报道,我国脊柱手术感染的风险从0.5%~7.8%不等[3-4]。糖尿病、肥胖、高血压等疾病显著增加脊柱术后感染,感染后治疗的费用可达10多万美元[5],大大增加了患者的经济负担。
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| 关 键 词： | 脊柱 骨疾病,感染性 疾病模型,动物 金黄色葡萄球菌 综述 |
Progress in the establishment and application of animal models of pyogenic spinal infection |
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| LI Jiang-bi,WANG Yong-jie,NA Shi-bo,WU Hong,LIU Jun,JI Xue,GONG Wei-quan,LIU Li-di,LV Zhen-shan,ZHANG Shao-kun. Progress in the establishment and application of animal models of pyogenic spinal infection[J]. Chinse Journal Of Bone and Joint, 2020, 0(1): 75-79 |
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| Authors: | LI Jiang-bi WANG Yong-jie NA Shi-bo WU Hong LIU Jun JI Xue GONG Wei-quan LIU Li-di LV Zhen-shan ZHANG Shao-kun |
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| Affiliation: | (Department of Spine Surgery,The First Hospital of Jilin University,Changchun,Jilin,130021,China) |
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| Abstract: | Infection after spine surgery is a very serious complication,which may lead to severe nerve injury,even death.Frequent use of clinical instruments increases its incidence.This article summarizes the advantages and disadvantages of each animal model to unveil its effectiveness simulating the process and lack of all-round evaluation on real-time observation rather than simple bacterial culture and histological analysis at a certain point.The application of immunofluorescence has achieved long-term monitoring of bioluminescent bacterial infections.However,microbiology,imaging and histopathology will be combined for a comprehensive assessment. |
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| Keywords: | Spine Bone diseases,infectious Disease models,animal Staphylococcus aureus Review |
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