Anti-ribosomal P antibodies are associated with nephritis, vascular thrombosis and lymphocytopenia in patients with systemic lupus erythematosus |
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Authors: | Takeda Isao Iwadate Haruyo Sugisaki Kota Takahashi Atsushi Nogae Syoji Kanno Takashi Kasukawa Reiji |
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Affiliation: | Division of Rheumatology, Ohta Nishinouchi Hospital, Koriyama, 963-8558, Japan. |
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Abstract: | In the present study, anti-ribosomal P antibody in sera of patients with systemic lupus erythematosus was assayed using an enzyme-linked immunosorbent assay, and its association with clinical symptoms of the patients was analyzed. The presence of anti-ribosomal P antibody was associated with increased frequency of lupus nephritis in the presence of anti-DNA antibody, and was associated with increased frequency of vascular thrombosis in the presence of anti-beta2 glycoprotein I antibody and/or lupus anticoagulant. The level of anti-ribosomal P antibody correlated inversely with the peripheral lymphocyte counts. |
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