Proliferative activity of oxyphilic (Hurthle) cells in reactive and neoplastic thyroid lersions |
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Authors: | Maria S Tretiakova MD Mauro Papotti MD Gianni Bussolati MD FRCPath |
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Institution: | (1) Department of Pathology, St. Petersburg State Medical, Academy, Russia;(2) Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, I-10126 Torino, Italy |
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Abstract: | The proliferative potential of oxyphilic (Hurthle) cells (HCs) present in neoplastic and non-neoplastic thyroid lesions is
uncertain. To estimate the HCs ability to proliferate and to determine whether their proliferative activity correlates with
the biologic behavior of different thyroid oxyphilic lesions, we selected 31 cases of chronic lymphocytic (Hashimoto’s) thyroiditis
and 28 oxyphilic (Hurthle cell) thyroid tumors, including 12 adenomas and 16 carcinomas. Seven histologically normal thyroid
specimens from euthyroid patients served as control tissue. The proliferative activity of HCs was evaluated by means of a
double immunostaining for Ki67 and a mitochondrial antigen (which specifically recognizes oxyphilic cells). Oxyphilic cells
in thyroiditis had a low proliferative activity (PA: 0.55%), although higher than that of normal thyroid parenchyma (PA: 0.06%).
Neoplastic HC lesions had a mean proliferative activity of 1.56% and 6.26% in adenomas and carcinomas, respectively. A statistically
significant difference was observed between proliferative activity of non-neoplastic and neoplastic lesions (p<0.01), but not within the tumor group, between adenomas and carcinomas. In addition, HC carcinomas had a statistically significant
positive correlation between proliferative activity and tumor size (p<0.01) and the presence of necrosis (p<0.001). |
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Keywords: | Thyroid oxyphilic (Hurthle) cells immunohistochemistry proliferation Ki67 mitochondrion-rich cells |
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