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| 分光光度法测定非布司他片的溶出度 | |
| 引用本文： | 赵丽云,杨更亮,潘友兰.分光光度法测定非布司他片的溶出度[J].河北职工医学院学报,2010,27(5):8-10. |
| 作者姓名： | 赵丽云 杨更亮 潘友兰 |
| 作者单位： | 1. 河北大学药学院,河北,保定,071000;北京美迪康信医药科技有限公司,北京,100022 2. 河北大学药学院,河北,保定,071000 3. 北京美迪康信医药科技有限公司,北京,100022 |
| 基金项目： | 国家自然科学基金资助项目 |
| 摘 要： | 目的建立非布司他溶出度的测定方法。方法依照《中国药典》2005年版二部附录溶出度项下第二法,磷酸盐缓冲液（pH6.8）为溶出介质,转速为50r/min,紫外可见分光光度法测定,检测波长为315nm。结果在1.813～18.131g/mL范围内（r=1.000）,浓度与吸光度呈良好的线性关系,平均回收率为99.93%,RSD为0.59%（n=9）。结论该法操作简便、准确可靠,可作为非布司他的质量控制方法。 |
| 关 键 词： | 非布司他 溶出度 紫外可见分光光度法 |
Dissolution determination of Febuxostat tablets by UV Spectrophotography |
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| Zhao Liyun,Yang Gengliang,Pan Youlan.Dissolution determination of Febuxostat tablets by UV Spectrophotography[J].Journal of Hebei Medical College for Continuing Education,2010,27(5):8-10. | |
| Authors: | Zhao Liyun Yang Gengliang Pan Youlan |
| Institution: | Zhao Liyun1,2,Yang Gengliang1,Pan Youlan2 (1.Pharmacy College of Hebei University,Baoding 071000,China,2.Beijing Medconxin Techonology Co.,Ltd.,Beijing 100022,China) |
| Abstract: | Objective To establish the dissolution determination of Febuxostat Tablets with UV spectroph otography.Methods According to the 2005 editional appendix of The Pharmacopoeia of the PRC,phosphate buffer with pH=6.8 was the dissolution medium,and the scan wavelength was 315nm.Results The absorption was good linear in the concentraion range of 1.813～18.131 g/mL （r=1.000）.The average recovery was 99.93%,RSD=0.59%（n=9）.Conclusion The method is good,simple and accurate,which can be used as quality control method. |
| Keywords: | Febuxostat dissolution UV Spectrophotography |
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