苏乐康胶囊抑制理化致癌因子诱发小鼠的肿瘤发生

本文用苏乐康胶囊,剂量为39mg,每天1次灌胃,连续7天,抑制~(60)钴γ线全身照射0.5Gy和二乙基亚硝胺(DENA)皮下注射,剂量为0.1mg,每周注射1次,共8次,诱发雄性LACA小鼠肺肿瘤的发生。该胶囊不仅明显地抑制和阻断肺肿瘤的发生,其发生率由80.0％降到26.1％,P<0.01,而且肺癌的发生率也明显降低,由26.7％降到0.0%,P<0.01。该胶囊阻断γ线和DENA的联合致癌作用机制与其中人参、黄芪、维生素E等具有还原和抗氧化作用有关,能捕获自由基,减轻或消除其对靶细胞的损伤。

Blocking Formation of Lung Tumors Induced by Carcinogens in Mice by "Sulekang" Capsule

Induction of lung tumors by "Co'irradiation combined with subcutaneous injection of diethylnitrosamine (DENA) in mice was effectively prevented by feeding "Sulekang"capsule (Anti-ageing drug). By so doing, the lung tumor incidence in treated mice decrease from 80% to 26.1% (P<0.01); and malignant lung tumor incidence from 26.7% to 0.0% (P<0.01). The mechanism of this tumor induction blockade can be well attributed to capture of free radicals produced by "Sulekang"carcinogens.