Squamous Cell Carcinoma of the Esophagus with Cartilaginous Metaplasia at Metastatic Lesions |
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| Authors: | Nobuyuki Terada Reiko Yamamoto Shingo Ishiguro Kenji Hata Masumi Sawada Yoshifumi Hiramatsu Koshiro Hioki Yukihiko Kitamura |
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| Affiliation: | Departments of Pathology, The Center for Adult Diseases, Osaka.;Departments of Gastrointestinal Oncology, The Center for Adult Diseases, Osaka.;Department of Internal Medicine, The Hanwa Hospital, Osaka;Department of Obstetrics and Gynecology, Kure National Hospital, Kure;Department of Surgery, Kansai Medical University, Osaka;Department of Pathology, Osaka University Medical School, Osaka. |
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| Abstract: | Subdermal metastatic nodules in a 62 year old male patient with esophageal carcinoma contained both car-cinomatous and chondroid areas. The carcinomatous areas showed the histology of poorly differentiated squamous cell carcinoma, and light microscopically an apparent transition could be traced from carcinomatous cells to chondroid cells. In the chondroid cells, the characteristics of chondrocytes were demonstrated by light microscopic, electron microscopic, histochemical and immunohistochemical studies, although nuclear atypism was evident, suggesting their malignancy. Furthermore, immunohistochemical studies showed that some chondroid cells contained both keratin proteins and squamous cell carcinoma antigen, which were also found in the carcinomatous cells. These findings together with the light microscopic observations suggest that chondroid cells are derived from squamous cell carcinoma cells. |
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| Keywords: | Esophageal carcinoma Squamous cell carcinoma Cartilaginous metaplasia |
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