辛伐他汀并氨氯地平对单纯收缩期高血压患者脉压的影响

目的观察辛伐他汀和氨氯地平联合用药对老年单纯收缩期高血压（ISH）患者脉压（PP）的影响。方法58例老年ISH患者被随机分为两组,对照组28例用氨氯地平（5mg/d）,治疗组30例用氨氯地平（5mg/d）加辛伐他汀（10mg/d）,观察12周,每两周随访血压1次并记录。结果在治疗12周时,对照组PP从治疗前（72.1±9.5）mmHg降至（63.8±7.7）mmHg;治疗组PP从治疗前（71.3±8.2）mmHg降至（58.9±6.1）mmHg。治疗前后两组PP之间差异有统计学意义（P〈0.01）。结论辛伐他汀和氨氯地平联合应用有助于改善老年ISH患者的PP。

Effect of Combined Treatment of Simvastatin and Amlodipine on Pulse Pressure in Senile Patients with Isolated Systolic Hypertension

Objective To observe the effects of combined treatment of simvastatin and Amlodipine on pulse pressure（PP） in senile patients with isolated systolic hypertension（ISH）.Methods 58 old patients with normal level cholesterol were divided into the 2 groups.Amlodipine of 5 mg/d dosage was taken by 28 subjects in control group.30 cases in treatment group were administered orally with Amlodipine of 5 mg/d dose and 10 mg/d simvastatin.Blood pressure was followed up and recorded every two weeks for 12 weeks.Results After treatment the PP decreased from pretreatment（72.1±9.5） mm Hg to（63.8±7.6） mm Hg in control group.Atorvastatin combined with Amlodipine resulted in a significant improvement of PP from pretreatment（71.3±8.2） mm Hg to（58.9±6.1） mm Hg.There was a significant difference between two groups for PP after treatment（P0.01）.Conclusion A combination treatment with simvastatin and Amlodipine is helpful to the PP improvement in old patients with ISH.