甲氨蝶呤联合米非司酮治疗输卵管妊娠疗效观察

目的:观察甲氨蝶呤联合米非司酮治疗输卵管妊娠的效果。方法:2008年1月至2010年6月我院收治98例未破裂型输卵管妊娠患者,随机分为研究组和对照组各49例,研究组采用甲氨碟呤联合米非司酮治疗,对照组给予甲氨碟呤治疗,比较两组的临床疗效及副反应。结果:研究组包块缩小率、血绒毛膜促性腺激素β(HCG-β)下降≥30%,平均住院时间与对照组比较,有统计学差异(P<0.05)。治疗后患侧输卵管再通率研究组(75.0%,24/32)明显高于对照组(64.3%,18/28)。结论:甲氨碟呤联合米非司酮保守治疗输卵管妊娠,方法简便,疗效高,疗程短,副作用小,可保留生育功能,被患者易于接受。

Curative effect of MTX combined with mifepristone in the treatment of tubal pregnancy

AIM: To observe the effectiveness of methotrexate combined with mifepristone for tubal pregnancy treatment.METHODS: A total of 98 cases of ectopic pregnancy were diagnosed as unrupture tubal pregnancy that be randomly divided into two groups from Jan.2008 to Jun.2010,each group 49 cases.Study group was treated with MTX single-dose(50 mg/m2) intramuscular injection combined with mifepristone.Control group was treated with MTX single-dose(50 mg/m2) intramuscular injection only.After treatment,the curative effect and adverse effect between the two groups were compared.RESULTS:The rate of tubal pregnancy package of block reduction and the serumβ-HCG descent exceeded 30% in study group.Less time of average hospitalization in study group significantly differed from the control group(P<0.05).And the lateral oviduct recanalization rate of the study group was 75.0%(24/32),which was higher than that of the control group 64.3%(18/28).CONCLUSION: The combination of single-dose MTX intramuscular injection with mifepristone in treating tubal pregnancy is effective and has minor side effect.The procreation function is reserved and it is acceptable for patients.