卡前列素氨丁三醇防治剖宫产术中、术后出血的临床研究

目的:探讨卡前列素氨丁三醇防治剖宫产术中、术后出血的临床疗效。方法:选择有出血高危因素行剖宫产术的产妇120例,分成研究组及对照组,每组60例。两组均在胎儿娩出后常规静脉滴注催产素的基础上,研究组于宫体注射卡前列素氨丁三醇250μg,对照组予卡孕栓1.0mg舌下含服,比较两组术中出血量、产后2h及产后2～24h内的出血量及两组产后出血率。比较两组患者用药前及用药后生命体征变化。结果:研究组术中出血量、产后2h出血量、产后2～24h出血量均少于对照组,差异均有统计学意义(P<0.05),研究组产后出血率低于对照组,差异有统计学意义(P<0.05);两组用药前、后生命体征变化相近,差异无统计学意义(P>0.05)。结论:卡前列素氨丁三醇可有效防治有出血高危因素产妇剖宫产术中、术后出血,快速方便,效果确切,不良反应少。

Clinical application of carboprost tromethamine on prevention and treatment of postpartum hemorrhage in cesarean section

AIM: To investigate the clinical efficacy of carboprost tromethamine on the prevention and treatment for hemorrhage during cesarean section(CS) and postoperative hemorrhage.METHODS: From Feb.to Oct.2011,120 cases undergone CS with high risk of PPH were divided randomly into two groups.After delivery 250 μg carboprost tromethamine was injected on the uterine body in study group,while methyl-carboprost suppository 1.0 mg by sublingual was given immediately in control group,both on the basis of oxytocin intravenous drip.The intraoperative blood loss,postpartum bleeding in 2 h and 2-24 h and the rate of postpartum hemorrhage were compared between two groups.The changes of vital signs before and after the treatment in two groups were observed.RESULTS:There were statistically significant differences between two groups on intraoperative blood loss,postpartum hemorrhage in 2 h and 2-24 h(P<0.05);And the incidence rate of postpartum hemorrhage in study group was less than that in control group(P<0.05).There were no significant differences on the change of vital signs before and after treatment(P>0.05)CONCLUSION: It was effective,rapid and convenient to use carboprost tromethamine for the prevention and treatment in high hemorrhagic risk fators of PPH during CS with less adverse reaction.