| 临床药代动力学和药效动力学研究中的采样优化方法 |
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| 引用本文： | 李燕,孙鹤. 临床药代动力学和药效动力学研究中的采样优化方法[J]. 中国临床药理学与治疗学, 2012, 17(9): 1014-1021 |
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| 作者姓名： | 李燕 孙鹤 |
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| 作者单位： | 天津大学药物科学与技术学院,天津,300072 |
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| 摘 要： | 采样优化方法在临床药代动力学和药效动力学研究中受到广泛关注.本文综述了D优化法、多元线性回归法、基于最大后验贝叶斯估算法(MAPB)的有限采样法等的原理、步骤及优缺点,并总结了各方法在采样优化估算中每一步骤的特点.本文也列举了重要的应用实例,介绍了可实现其估算分析的统计软件.
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| 关 键 词： | 药代动力学 药效动力学 采样优化 D最优 多元线性回归法 最大后验贝叶斯法 |
Optimal sampling methods in pharmacokinetic and pharmacodynamic studies |
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| LI Yan , SUN He. Optimal sampling methods in pharmacokinetic and pharmacodynamic studies[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(9): 1014-1021 |
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| Authors: | LI Yan SUN He |
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| Affiliation: | School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China |
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| Abstract: | Optimal sampling strategies were concerned in many pharmacokinetic and pharmacodynamic researches.The principles,procedures,characteristics and computational methods of D-optimality,limited sampling using multiple linear regression,and limited sampling using maximum a posteriori Bayesian estimation(MAPB) are presented and compared in this review.Several typical application examples of optimal sampling and partial available software are provided in this article. |
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| Keywords: | Pharmacokinetics Pharmacodynamics Optimal sampling D optimality Multiple linear regression Maximum a posteriori Bayesian estimation |
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