| 胡桃醌对小鼠黑色素瘤细胞B16F10体内迁移的影响 |
| |
| 引用本文： | 陈丽,张建,汪思应,黄德武,顾为望.胡桃醌对小鼠黑色素瘤细胞B16F10体内迁移的影响[J].中国临床药理学与治疗学,2012,17(9):978-982. |
| |
| 作者姓名： | 陈丽 张建 汪思应 黄德武 顾为望 |
| |
| 作者单位： | 1. 安徽医科大学实验动物中心,合肥230032,安徽
2. 南方医科大学实验动物中心暨比较医学研究所,广州510515,广东 |
| |
| 基金项目： | 安徽医科大学校博士科研资助经费(XJ200906) |
| |
| 摘 要： | 目的:研究胡桃醌对小鼠黑色素瘤细胞B16F10体内迁移的影响.方法:采用小鼠B16/F10黑色素瘤人工肺转移模型研究胡桃醌对肿瘤细胞血道转移的作用.结果:与溶剂对照组相比,4.5、3、1.5和0.75 mg/kg胡桃醌组显著减少小鼠黑色素瘤B16F10血道转移(P＜0.05),其抑制率分别为27.30％、55.35％、31.52％和25.34％;3 mg/kg胡桃醌与阳性对照组相比,抑瘤率无统计学差异(P＞0.05).结论:胡桃醌可抑制小鼠黑色素瘤B16F10血道转移.
|
| 关 键 词： | 胡桃醌 B16F10 血道转移 |
The inhibitory effect of juglone on the metastasis of skin melanoma cell line B16F10 |
| |
| CHEN Li
,
ZHANG Jian
,
WANG Si-ying
,
HUANG De-wu
,
GU Wei-wang.The inhibitory effect of juglone on the metastasis of skin melanoma cell line B16F10[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2012,17(9):978-982. |
| |
| Authors: | CHEN Li ZHANG Jian WANG Si-ying HUANG De-wu GU Wei-wang |
| |
| Institution: | 1 Laboratory Animal Center,Anhui Medical University,Hefei 230032,Anhui,China;2 Laboratory Animal Center&Department of Comparative Medicine,Southern Medical University,Guangzhou 510515,Guangdong,China |
| |
| Abstract: | AIM: To investigate the inhibitory effect of juglone on the metastasis of skin melanoma cell line B16F10.METHODS: B16-F10 cells were injected into the tail veins of C57BL/6 mice to establish an experimental lung metastasis model,and the effect of juglone on lung metastasis was observed.RESULTS:The number of metastases in the animals that were given juglone 4.5,3,1.5 and 7.5 mg·kg-1·d-1 was significantly reduced as compared with the vehicle control(P<0.05),and the inhibition rates were 27.30%,55.35%,31.52%,25.34%,respectively.Compared with the positive control group,the inhibitory rate of 3 mg/kg juglone was no significant difference(P>0.05).CONCLUSION: Juglone could inhibit melanoma metastasis of B16F10. |
| |
| Keywords: | Juglone B16F10 cell Hematogenous metastasis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
