转移性非小细胞肺癌的化学治疗现状与进展

近年来,吸烟、污染以及油烟等导致肺癌的发病率及病死率迅速增长。非小细胞肺癌起病隐匿,发展迅速,预后差,患者初诊时多数即发生转移(IV期),失去手术机会,化疗是其主要的治疗方法,目的在于延长生存期、提高生活质量。目前临床应用的化疗药物主要是铂类以及第三代细胞毒药物。基于功能基因组学和蛋白组学的个体化治疗,为每一位肺癌患者设计最佳治疗策略是2l世纪临床发展的方向和理想的治疗模式。本文就转移性非小细胞肺癌的化学治疗现状与进展作一文献综述。

Recent status and progress of chemotherapy treatment for metastatic non-small-cell lung cancer

In recent years,smoking,pollution and lampblack lead to the morbidity and mortality of lung cancer rapid growth.Non-small-cell lung cancer onset occult,development is rapid,and the prognosis is poor.Most of the patients with newly diagnosed is transferred(IV stage) and lost the opportunity to surgery,chemotherapy is the main treatment method,which purpose is to prolonging the survival time and the quality of life.At present clinical application of chemotherapy is mainly platinum-based and the third generation cytotoxic drugs.The best treatment strategy which based on functional genomics and proteomics in individual therapy design for every patient with lung cancer is the direction of the clinical development and the ideal mode of treatment of the 2lcentury.This paper reviews the recent status and progress of chemotherapy treatment for metastatic non-small-cell lung cancer.