地塞米松软膏对预防诺维苯所致静脉炎的效果观察

目的 观察地塞米松软膏外涂预防诺维苯所致静脉炎的效果.方法 将经外周浅静脉行诺维苯化疗的恶性肿瘤患者按首次入院时日期单双号分为观察组和对照组.观察组70例,对照组72例,平均使用诺维苯4次.观察组化疗第1天开始采用地塞米松软膏外涂沿穿刺静脉走向皮肤10～12cm,连续3d,2～3次/d;对照组采用常规护理方法,观察比较2组静脉炎的发生率,发生时间及程度.所有数据均行X2检验.结果 观察组静脉炎发生率较对照组明显降低,2组比较差异有统计学意义(P<0.01);观察组静脉炎发生严重程度较对照组轻(P<0.05);观察组静脉炎发生时间也比对照组明显延缓,差异有统计学意义(P<0.05).结论 地塞米松软膏外涂能有效预防诺维苯外周静脉化疗后外周浅静脉炎的发生.

Effect of dexamethasone ointment on preventing phlebitis induced by vinorelbine

Objective We observed the effect of dexamethasone ointment on preventing phlebitis induced by vinorelbine. Methods Patients with malignant tumor who received chemotherapy of vinorelbine through peripheral superficial vein injection were divided into the observation group (70 cases) and the control group (72 cases) according to the date of hospitalization. All patients received vinorelbine four times averagely. Patients in the observation group was given dexamethasone ointment along punctured superficial vein. Patients in the control group received routine nursing measure. The incidence rate, time and degree of phlebitis was compared between these groups. Results The incidence rate and degree of phlebitis was lower than those of the control group (P< 0.01, P< 0.05). The incidence time of phlebitis in the observation group was also later than that of the control group (P<0.05). Conclusion Local application of dexamethasone ointment could effectively reduce the incidence of superficial phlebitis caused by vinorelbine chemotherapy.