Sleep-Related Autonomic Disturbances in Symptom Subgroups of Women with Irritable Bowel Syndrome |
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Authors: | Jennifer J T Robert Sigrid Elsenbruch William C Orr |
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Institution: | (1) Thomas N. Lynn Institute for Healthcare Research, 5300 North Independence, Suite 130, Oklahoma City, Oklahoma 73112, USA;(2) Department of Medical Psychology, University Clinic of Essen, Essen, Germany;(3) Thomas N. Lynn Institute for Healthcare Research, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA |
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Abstract: | The objective was to investigate whether predominant symptom patterns in women with irritable bowel syndrome (IBS) affect
autonomic activity during sleep. Seventy-five women with IBS underwent a polysomnographic sleep study. Twenty-two of the IBS
patients were diarrhea-predominant (IBS-D), 33 were constipation-predominant (IBS-C), and 20 patients had alternating symptoms
(IBS-A). Autonomic activity was measured by heart rate variability. The IBS-D group had significant vagal withdrawal compared
to the IBS-A group during REM and non-REM sleep (P < 0.05). The IBS-D symptom subgroup had significantly (P < 0.05) greater sympathetic dominance during non-REM than IBS-A patients. Lower abdominal pain correlated with sympathetic
dominance during sleep in the IBS-D group (r=0.54, P < 0.01). The IBS-D patients were physiologically distinct with regard to autonomic functioning during sleep compared to the
alternating patients, but not the constipated patients. Sleep appears to unmask differences in autonomic activity that may
distinguish IBS patients. |
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Keywords: | Autonomic nervous system Constipation predominant Diarrhea predominant Heart rate variability Irritable bowel syndrome Sleep |
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