Risk factors for type I diabetes mellitus in children in Austria |
| |
Authors: | B Rami U Schneider A Imhof T Waldhör E Schober |
| |
Institution: | University Children's Hospital Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria, e-mail: Edith.Schober@akh-wien.ac.at, Tel.: +43-1-40400-3232, Fax: +43-1-40400-3238, AT Department of Paediatrics, General Hospital of St. P?lten, Austria, AT Institute for Tumour Biology and Cancer Research, University of Vienna Medical School, Vienna, Austria, AT
|
| |
Abstract: | The aim of this study was to investigate environmental risk factors in the development of type 1 diabetes mellitus in a population-based
case-control study. Parents of all patients with manifestation of type 1 diabetes between 1989 and 1994 in Vienna were asked
to complete a questionnaire (n = 114). Control children (n = 495), matched for age and sex, were randomly recruited from all schools in Vienna. Fathers of diabetic children were significantly
older at the time their children were born than fathers of control children (P = 0.015). Children with diabetes were more likely to be second- or third-born children (P < 0.05) and fewer went to kindergarten than the control group children (P = 0.007). No significant difference in duration of gestation, percentage of delivery by caesarean section, birth weight or
length was found. Neonatal jaundice was more often observed in the patient group (P = 0.038). Breast feeding was reported by 82.7% of mothers of diabetic children and by 81% of mothers of control children,
and the duration of breast feeding was longer in patients than in controls (n.s.).
Conclusion In our study, the development of type 1 diabetes mellitus was associated with higher paternal age and neonatal jaundice.
No correlation could be found with dietary intake of cow's milk products in early infancy, vaccination and other environmental
factors.
Received: 5 May 1998 / Accepted in revised form: 27 August 1998 |
| |
Keywords: | Type 1 diabetes Children Risk factors Case control Environmental |
本文献已被 SpringerLink 等数据库收录! |
|