Integration of the PRB and P53 Cell Cycle Control Pathways |
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| Authors: | Stewart Craig L. Moro Soria Alejandro Hamel Paul A. |
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| Affiliation: | (1) Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada;(2) Centre for Genetic Engineering and Biotechnology, Havana, Cuba |
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| Abstract: | Two fundamental molecular pathways, the pRB and p53 pathways, regulate cell growth and cell death. The importance of these pathways in cellular growth control is underscored by the observation that members of these pathways are found mutated in all human cancer. These two pathways have typically been studied and described independently. However, as we discuss here, recent data have revealed an intimate molecular and genetic interaction between the p53 and pRB pathways. |
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| Keywords: | pRB p53 cell cycle cell growth cell death tumor suppressor gene |
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